Cancer Detoxification Model
Product Code : JC-BE-6153
The Cancer Detoxification Model from Jaincolab is a three-dimensional teaching model that illustrates how cancer cells detoxify chemotherapy drugs and reactive metabolites to survive treatment.
It is used in biochemistry and oncology courses to explain the glutathione detoxification system, drug efflux pumps, and how these mechanisms contribute to multidrug resistance.
What the Concept States
| Parameter | Details |
|---|---|
| Glutathione System | Major antioxidant and detoxification pathway that neutralises reactive oxygen species and xenobiotics in cancer cells |
| Glutathione S-Transferases | Enzymes that conjugate glutathione to toxic compounds and chemotherapy drugs |
| P-Glycoprotein (ABC Transporters) | Efflux pumps that expel drugs from cancer cells, reducing intracellular drug concentration |
| Multidrug Resistance | Reduced chemotherapy effectiveness resulting from enhanced detoxification and efflux mechanisms |
| Reactive Oxygen Species (ROS) Management | Cancer cells upregulate antioxidant defences to survive oxidative stress |
| Detoxification Enzyme Upregulation | Increased expression of Phase I and Phase II enzymes contributing to chemoresistance |
Key Features
- Shows the glutathione detoxification pathway in cancer cells
- Illustrates P-glycoprotein-mediated drug efflux
- Explains the molecular basis of multidrug resistance
- Durable, exam-oriented construction for repeated classroom use
- Compact benchtop format suitable for laboratories and lecture halls
Why Choose Jaincolab
Jaincolab (Jain Scientific Suppliers) is an ISO 9001:2015 and ISO 14001:2015 certified manufacturer and exporter of laboratory and scientific teaching models, supplying biology, chemistry, physics, and pharmacy equipment to institutions across India and internationally. Explore our complete range on the Biology Equipment category page, including our Cancer Metabolism Model, for related oncology teaching aids.
Applications
| Application Area | Use |
|---|---|
| Biochemistry Education | Teaching cancer cell detoxification and drug resistance mechanisms |
| Oncology Colleges | Correlating detoxification pathways with chemotherapy resistance |
| Biotechnology Training | Supporting coursework on drug resistance-targeted therapies |
| Pathology Laboratories | Explaining biomarkers linked to multidrug resistance |
| Science Exhibitions | Visual overview of cancer detoxification mechanisms for general audiences |
Frequently Asked Questions
Q1. What does the Cancer Detoxification Model demonstrate?
A. It demonstrates how cancer cells use the glutathione system and drug efflux pumps to detoxify and resist chemotherapy drugs.
Q2. What role does glutathione play in cancer cells?
A. Glutathione neutralises reactive oxygen species and xenobiotics, and glutathione S-transferases conjugate it to toxic compounds and drugs.
Q3. What is P-glycoprotein?
A. P-glycoprotein is an ABC transporter that pumps drugs out of cancer cells, reducing the intracellular drug concentration.
Q4. What is multidrug resistance?
A. Multidrug resistance is reduced chemotherapy effectiveness resulting from enhanced cellular detoxification and drug efflux mechanisms.
Q5. Who uses this model?
A. Biochemistry, oncology, and biotechnology students and faculty use it to study cancer detoxification mechanisms.
Request a Quote
To request pricing or place an order for the Cancer Detoxification Model, please contact our team with your requirement.
