Mechanism of Shigella Infection Model
Product Code : JC-BE-6190
The Mechanism of Shigella Infection Model from Jaincolab is a three-dimensional teaching model that illustrates how Shigella species invade the colonic epithelium to cause bacillary dysentery.
It is used in microbiology courses to explain the invasion, intracellular spread, and toxin production that characterize Shigella pathogenesis.
What the Concept States
| Parameter | Details |
|---|---|
| Causative Organism | Shigella species are Gram-negative, non-motile, non-lactose-fermenting rods within the Enterobacteriaceae family |
| Entry via M Cells | Shigella crosses the intestinal epithelium through specialized M cells overlying lymphoid follicles |
| Epithelial Invasion | The bacterium invades colonic epithelial cells and escapes the phagocytic vacuole into the cytoplasm |
| Intracellular Spread | Actin-based motility propels the bacterium directly into adjacent cells, avoiding extracellular immune defenses |
| Shiga Toxin | Shigella dysenteriae type 1 produces Shiga toxin, which inhibits protein synthesis and damages the intestinal mucosa |
Key Features
- Illustrates the step-by-step invasion mechanism of Shigella in the colon
- Shows M cell entry, epithelial invasion, and actin-based intracellular spread
- Explains the role of Shiga toxin in disease severity
- Durable, exam-oriented construction for repeated classroom use
- Compact benchtop format suitable for laboratories and lecture halls
Why Choose Jaincolab
As a trusted biology lab equipment supplier in India, Jaincolab (Jain Scientific Suppliers) is an ISO 9001:2015 and ISO 14001:2015 certified manufacturer and exporter of laboratory and scientific teaching models, supplying biology, chemistry, physics, and pharmacy equipment to institutions across India and internationally. Explore our complete range on the Biology Equipment category page, including our Escherichia and Salmonella Species Model and Enterobacteriaceae Model, for related microbiology teaching aids.
Applications
| Application Area | Use |
|---|---|
| Microbiology Education | Teaching the pathogenesis of Shigella-induced dysentery |
| Medical Colleges | Explaining the cellular mechanism of bacterial invasion and spread |
| Public Health Training | Understanding fecal-oral transmission and outbreak control of shigellosis |
| Pediatric Training | Correlating Shigella infection with childhood diarrheal disease |
| Science Exhibitions | Visual overview of bacterial invasion mechanisms for general audiences |
Frequently Asked Questions
Q1. What does the Mechanism of Shigella Infection Model demonstrate?
A. It demonstrates how Shigella species invade the colonic epithelium to cause bacillary dysentery.
Q2. How does Shigella enter the intestinal lining?
A. Shigella crosses the intestinal epithelium through specialized M cells overlying lymphoid follicles.
Q3. How does Shigella spread between cells?
A. It uses actin-based motility to propel itself directly into adjacent epithelial cells, avoiding extracellular immune defenses.
Q4. What is Shiga toxin?
A. Shiga toxin, produced by Shigella dysenteriae type 1, inhibits protein synthesis and damages the intestinal mucosa.
Q5. Who uses this model?
A. Microbiology and medical students and faculty use it to study the pathogenesis of Shigella infection.
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